Abstract #4074

Neurochemical Alterations and Behavioral Impairments in Late Stage Alcoholic Liver Fibrosis in Mice

Su Xu^1,2, Wenjun Zhu^1,2, JiaBei Wang³, Xi Chen⁴, Rao P Gullapalli^1,2, Edward Herskovits¹, Elias Melhem¹, and Qi Cao¹

¹Radiology, University of Maryland School of Medicine, Baltimore, MD, United States, ²Core for Translational Research in Imaging @Maryland, Baltimore, MD, United States, ³Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, United States, ⁴Harvard Medical School McLean Hospital, Belmont, MA, United States

A mouse model of late-stage alcoholic liver fibrosis (LALF) was used to investigate changes of neurochemical levels in specific brain regions that may relate to behavioral changes at LALF. Higher glutamine levels result in osmotic/oxidative stress were found in the thalamus and hippocampus of the alcohol-treated mice than in controls. Thalamic levels of taurine and creatine were significantly diminished and were strongly correlated with the alcohol-induced depressive behavior observed in an open field test. In addition, significant elevations in hippocampal glutamate were indicative of upregulated local glutamatergic activation. These pilot findings provide novel insight into the development of alcohol-induced HE.

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