Abstract #4073

Effect of administration time of hydrogen sulfide on neuroprotective effects in the cerebral ischemia/reperfusion injury model

Chul-Woong Woo¹, Jae Im Kwon¹, Sang Tae Kim¹, Kyung won Kim², YoonSeok Choi³, Jinil Kim¹, Jeong Kon Kim², Su Jeong Ham¹, Seul I Lee¹, Ho-jin Kim¹, Jeeheon Kang¹, and Dong-Cheol Woo¹

¹Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ²Department of Radiology, Asan Medical Center, ³Medical research institute, Gangneung Asan Hospital

Recent evidence indicated that hydrogen sulfide is capable of attenuating ischemia/reperfusion (I/R) injury in brain. However, the influence of H₂S administration timing on its neuroprotective efficacy has not yet been assessed, thus we aimed to perform this study which used MRI and ¹H-MRS in rats with focal cerebral I/R injury. Our study demonstrated that hydrogen sulfide administration at 1 minute before reperfusion showed better neuroprotective effect than that at 30 minutes before reperfusion.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.