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Abstract #4073

Effect of administration time of hydrogen sulfide on neuroprotective effects in the cerebral ischemia/reperfusion injury model

Chul-Woong Woo1, Jae Im Kwon1, Sang Tae Kim1, Kyung won Kim2, YoonSeok Choi3, Jinil Kim1, Jeong Kon Kim2, Su Jeong Ham1, Seul I Lee1, Ho-jin Kim1, Jeeheon Kang1, and Dong-Cheol Woo1

1Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, 2Department of Radiology, Asan Medical Center, 3Medical research institute, Gangneung Asan Hospital

Recent evidence indicated that hydrogen sulfide is capable of attenuating ischemia/reperfusion (I/R) injury in brain. However, the influence of H2S administration timing on its neuroprotective efficacy has not yet been assessed, thus we aimed to perform this study which used MRI and 1H-MRS in rats with focal cerebral I/R injury. Our study demonstrated that hydrogen sulfide administration at 1 minute before reperfusion showed better neuroprotective effect than that at 30 minutes before reperfusion.

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