Abstract #4072

Resting-state functional connectivity reveals deep brain stimulation and 5-HT treated alteration in autism rat

Ssu-Ju Li¹, Hui-Yu Wang¹, Hui-Ching Lin^2,3, Ting-Chun Lin¹, Han-Fang Wu², Chi-Wei Lee², Yu-Chun Lo⁴, You-Yin Chen¹, and Hsin-Yi Lai⁵

¹Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, ²Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan, ³Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ⁴The PhD Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan, ⁵Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University, Hangzhou City, Zhejiang Province, People's Republic of China

This study demonstrates changes of functional connectivity in motor related brain areas and the motor cortex and striatum may be crucial areas for treatment and evolution of autism spectrum disorder (ASD). Our results indicate that both CT-DBS and 5-TH treatments can alter the social interaction and motor related functional connectivity VPA-induced ASD rats by modifying the motor cortico-striatal circuit. The rsfMRI has the potential to explore functional connectivity in the brain and monitor functional plasticity changes in a specific neuroanatomical pathway in vivo.

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