Resting state functional magnetic resonance imaging (rsfMRI) has opened a new window into the brain and its connectome, proposing abnormal functional connectivity as a candidate biomarker of brain pathologies1. We explored this pathway and performed rsfMRI and network analysis in the Thy-Tau22 transgenic mouse model of Alzheimer’s disease, evaluating possible network signatures of early pathological states. We mapped the brain functional connectivity patterns and found overactive resting state BOLD signal in core players of the memory and learning systems, including the hippocampal network. This correlates with subtle memory deficits characterizing a very early pathological phenotype of the Thy-Tau22 mouse model.
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