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Abstract #4083

Imaging plasticity associated with hippocampal kindling using simultaneous LFP-ofMRI

Ben A Duffy1, ManKin Choy1, and Jin Hyung Lee2

1Department of Neurology, Stanford University, Stanford, CA, United States, 2Departments of Neurology, Bioengineering, Neurosurgery, Electrical Engineering, Stanford University, Stanford, CA, United States

The kindling model of epilepsy is associated with a permanent form of synaptic potentiation, which is considered to be pathological. In this study we used optogenetic fMRI to observe changes in plasticity that occur following a kindling regime. Upon stimulation of the ventral hippocampus, post-kindling fMRI data displayed significantly more widespread activation, particularly in pre-frontal regions compared to pre-kindling acquisitions. Simultaneous LFP measurements were used to confirm the absence of epileptic activity that would confound the interpretation. This represents a powerful technique which can be used for understanding cognitive impairments or understanding the mechanism of anti-epileptogenic therapies.

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