Synchrotron microbeam radiation therapy (MRT), a spatially fractionated preclinical radiotherapy, is more efficient than broad beam irradiation (BB) at opening the blood-brain tumor barrier of intracranial rodent glioblastomas. MRT-induced increase of tumor vascular permeability is significantly greater, earlier and more prolonged than in the BB alone group, especially in highly proliferative areas. MRT targeted all tumor regions, including areas not impacted by BB. High dose microbeams might be used to facilitate the delivery of intravenously injected drugs to tumoral tissue: Adjuvant chemotherapy might thus be more effective when coupled with MRT than with homogeneous radiation fields used in conventional radiotherapy.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords