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Abstract #4084

MRI monitoring of the in vivo permeability increase of brain tumor vessels induced by synchrotron microbeam radiation therapy

Audrey Bouchet1,2, Marine Potez3, Nicolas Coquery 3, Claire Rome3, Benjamin Lemasson3, Elke Bräuer-Krisch4, Chantal Rémy3, Jean Albert Laissue5, Emmanuel Luc Barbier3, Valentin Djonov5, and Raphael Serduc3

1INSERM, Grenoble, France, 2University of Bern, Bern, Switzerland, 3INSERM, 4ESRF, 5University of Bern

Synchrotron microbeam radiation therapy (MRT), a spatially fractionated preclinical radiotherapy, is more efficient than broad beam irradiation (BB) at opening the blood-brain tumor barrier of intracranial rodent glioblastomas. MRT-induced increase of tumor vascular permeability is significantly greater, earlier and more prolonged than in the BB alone group, especially in highly proliferative areas. MRT targeted all tumor regions, including areas not impacted by BB. High dose microbeams might be used to facilitate the delivery of intravenously injected drugs to tumoral tissue: Adjuvant chemotherapy might thus be more effective when coupled with MRT than with homogeneous radiation fields used in conventional radiotherapy.

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