Abstract #4092

Imaging of glutamate alterations in a mouse model of temporal lobe epilepsy

Niels Leonard Schwaderlapp¹, Philipp Janz², Jochen Leupold¹, Dominik von Elverfeldt¹, Jan Korvink³, Jürgen Hennig¹, Carola Haas², and Pierre LeVan¹

¹Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, ²Dept. of Neurosurgery, Experimental Epilepsy, University Medical Center Freiburg, ³Institute of Microstructure Technology, Karlsruhe Institute of Technology

Hippocampal sclerosis involves neuronal loss in hippocampal subfields and is a common characteristic of temporal lobe epilepsy (TLE). Investigation of the metabolic alterations following a status epilepticus may lead to a better understanding of epileptogenesis and can reveal biomarkers for TLE. Overcoming the major disadvantages of single voxel ¹H MR spectroscopy, namely a low spatial and temporal resolution, this study investigates the capability of the glutamate chemical exchange saturation transfer (GluCEST) method to map endogenous glutamate alterations in a mouse model of TLE.

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