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Abstract #4093

Hyperpolarized Water Perfusion in the Porcine Brain – a Pilot Study

Esben Søvsø Szocska Hansen1,2, Kasper Wigh Lipsø3, Rasmus Stilling Tougaard1,4, Christoffer Laustsen1, and Jan Henrik Ardenkjær-Larsen3,5

1The MR Research Centre, Aarhus University, 8200, Denmark, 2Danish Diabetes Academy, Odense, Denmark, 3Department of Electrical Engineering, Technical University of Denmark, 4Department of Cardiology, Aarhus University Hospital, Denmark, 5GE Healthcare, Denmark

Dynamic Contrast-Enhanced MR (DCE-MR) perfusion assessment with gadolinium contrast agents is currently the most widely used cerebral perfusion MR method. Hyperpolarized water has recently been shown to succeed 13C probes as angiography probe. In this study, we demonstrate the feasibility of hyperpolarized water for visualizing the brain vasculature of a large animal in a clinically relevant setting. In detail, reference perfusion values were obtained and large to small arteries could be identified.

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