Abstract #4093

Hyperpolarized Water Perfusion in the Porcine Brain – a Pilot Study

Esben Søvsø Szocska Hansen^1,2, Kasper Wigh Lipsø³, Rasmus Stilling Tougaard^1,4, Christoffer Laustsen¹, and Jan Henrik Ardenkjær-Larsen^3,5

¹The MR Research Centre, Aarhus University, 8200, Denmark, ²Danish Diabetes Academy, Odense, Denmark, ³Department of Electrical Engineering, Technical University of Denmark, ⁴Department of Cardiology, Aarhus University Hospital, Denmark, ⁵GE Healthcare, Denmark

Dynamic Contrast-Enhanced MR (DCE-MR) perfusion assessment with gadolinium contrast agents is currently the most widely used cerebral perfusion MR method. Hyperpolarized water has recently been shown to succeed 13C probes as angiography probe. In this study, we demonstrate the feasibility of hyperpolarized water for visualizing the brain vasculature of a large animal in a clinically relevant setting. In detail, reference perfusion values were obtained and large to small arteries could be identified.

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