Abstract #4098

Assessment of subcortical white matter myelination progression based on T2WI visual evaluation during the age of 6-48 months: a DTI-based validation study

Congcong Liu¹, Zhijie Jian², Xianjun Li², Chao Jin³, Miaomiao Wang³, Heng Liu³, and Jian Yang³

¹Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an,China, People's Republic of China, ²Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P.R. China, ³Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P.R. China, People's Republic of China

Assessment of WM myelination is important to diagnose WM disorders in infants and children. We retrospectively evaluated 109 subjects (age of 6-48 months) using modified Cecilia Parazzini’s scoring method based on T2WI visual evaluation. A significantly positive correlation was found between age and total scores of WM myelination with non-linear correlation coefficient of 0.948 (p<0.01). TBSS results demonstrated WM myelination progressed rapidly during age of 6-20 months and relatively stable during age of 21-48 months. The modified scoring method was more applicable to assess the WM myelination in infant with age of 6-20 months.

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