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Abstract #4108

Characterizing brain microstructural changes in childhood arterial ischemic stroke using multi-shell diffusion magnetic resonance imaging

Joseph Yuan-Mou Yang1,2,3, Richard Beare3,4, Belinda Stojanovski2,5, Wirginia J Maixner1,2, Marc L Seal3,6, and Mark T Mackay2,5

1Neurosurgery, Royal Children's Hospital, Melbourne, Australia, 2Neuroscience Research, Murdoch Childrens Research Institution, Melbourne, Australia, 3Developmental Imaging, Murdoch Childrens Research Institution, Melbourne, Australia, 4Stroke and aging research group, Department of Medicine, Monash University, Melbourne, Australia, 5Neurology, Royal Children's Hospital, Melbourne, Australia, 6Paediatrics, University of Melbourne, Melbourne, Australia

Imaging markers that can infer microstructural changes occurring in childhood arterial ischemic stroke (CAIS) may lead to a better understanding of the disease’s neurobiological substrates. We applied both the Neurite Orientation Dispersion and Density Imaging (NODDI) and the Spherical Mean Technique (SMT) diffusion compartment models to two-shell diffusion data acquired in four acute CAIS patients. We demonstrate that parameter estimates derived from the stroke-affected regions were consistent with known microstructural changes described in acute stroke histopathology. The magnitudes of parameter changes were associated with stroke severity, and the motor outcomes at follow-up.

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