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Abstract #4109

Amide proton transfer imaging of neonatal brain injury: a preliminary study

Yang Zheng1, Xiaoming Wang2, and Xuna Zhao3

1Shengjing Hospital of China Medical University, shenyang, People's Republic of China, 2Shengjing Hospital of China Medical University, People's Republic of China, 3Philips Healthcare, People's Republic of China

The environment of the brain dynamically changes with neonatal brain development, and the topic of whether the application of magnetic resonance imaging (MRI) can reflect these brain environment changes is a recent one. In recent years, a new magnetic resonance contrast technology called amide proton transfer (APT) imaging has emerged which can detect protein and peptides through the signal from water (1), reflecting in vivo pH and protein concentration at the cellular and molecular level. The so-called amide proton mainly refers to the amide proton from the free protein and the polypeptide backbones.

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