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Abstract #4118

Detecting Perfusion Deficit in AD and MCI by Resting-State Functional MRI

Tianyi Qian1, Zhigang Qi2, and Kuncheng Li2

1MR Collaboration NE Asia, Siemens Healthcare, Beijing, People's Republic of China, 2Radiology, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China

Resting-state fMRI has been widely used to investigate the functional deficits of Alzheimer's disease (AD) and mild cognitive impairment (MCI). In this study, we applied this method to investigate the differences in tissue perfusion deficits between MCI, AD, and normal control (NC) groups. The results show that the AD and MCI groups have areas with less fast perfusion than normal controls. While the MCI group has more perfusion deficits in the frontal lobe, the AD group has more perfusion deficits in the parietal and occipital lobe.

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