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Abstract #4119

Degeneracy between apolipoprotein E ε3 and ε4 alleles predicts elderly episodic memory variation: a longitudinal study with independent validation

Hao Shu1,2, Gang Chen2, Zan Wang1, Duan Liu1, Guangyu Chen2, B. Douglas Ward2, Chunxian Yue1, Fan Su1, Lihua Gu1, Feng Bai1, Shi-Jiang Li2, and Zhijun Zhang1

1Department of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, People's Republic of China, 2Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

We reported distinct EM neural correlates among APOE alleles in elderly subjects but still unclear whether and how the APOE ε4 carriers’ distinct EM neural correlates contribute to an increased risk of AD onset. This study found that higher HFC strength in the EM neural correlates correlated with better longitudinal EM performance in the APOE ε3ε3 subjects but associated with inferior longitudinal EM performance in the ε4 carriers. These findings indicate that the degeneracy of EM function advance differential AD onset risk among APOE alleles, and provide a potential tool to predict APOE ε4 carriers with impending cognitive decline.

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