We reported distinct EM neural correlates among APOE alleles in elderly subjects but still unclear whether and how the APOE ε4 carriers’ distinct EM neural correlates contribute to an increased risk of AD onset. This study found that higher HFC strength in the EM neural correlates correlated with better longitudinal EM performance in the APOE ε3ε3 subjects but associated with inferior longitudinal EM performance in the ε4 carriers. These findings indicate that the degeneracy of EM function advance differential AD onset risk among APOE alleles, and provide a potential tool to predict APOE ε4 carriers with impending cognitive decline.
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