Abstract #4126

The effects of a Western-type diet on the cerebrovascular response to hypercapnia in a double transgenic mouse model for Alzheimer's Disease

Kristof Govaerts¹, Jessica Sternisa¹, Tom Dresselaers², Fred Van Leuven³, and Uwe Himmelreich¹

¹Imaging & Pathology, KU Leuven, Leuven, Belgium, ²Radiology, UZ Leuven, Leuven, Belgium, ³Human Genetics, KU Leuven, Leuven, Belgium

Alzheimer's Disease (AD) is the most common neurodegenerative disease, and is influenced by various environmental factors. In this study, we evaluate the effect of a high-fat, high-sugar ‘Western-type’ diet on the on the vascular response capacity to hypercapnia in a double transgenic (APP/PS1) mouse model of AD. We make use of Arterial Spin Labelling to investigate basal perfusion and cerebrovascular response to hypercapnia (CVR) in the hippocampus, cortex and thalamus.

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