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Abstract #4127

Can measuring hippocampal atrophy over a 3 year interval with a fully automatic method be substantially less noisy than manual?

Keith S Cover1, Ronald A van Schijndel2, Adriaan Versteeg2, Alberto Redolfi3, Paolo Bosco3, Soheil Damangi4, Bob W van Dijk1, Hugo Vrenken1,2, Giovanni B Frisoni3,5, and Frederik Barkhof2

1Physics and Medical Technology, VU University Medical Center, Amsterdam, Netherlands, 2Radiology, VU University Medical Center, Amsterdam, Netherlands, 3IRCCS SanGiovannidiDioFatebenefratelli, Italy, 4KarolinskaInstitutet, Stockholm, Sweden, 5University Hospitals and University of Geneva, Switzerland

The segmentation noise of hippocampal atrophy measurement methods can be measured using the back-to-back (BTB) reproducibility with the ADNI1 data set. Previous studies have only measured the segmentation noise over a one year interval. In the current study, two methods are shown to be substantially less noisy than manual hippocampal atrophy measurements over both 1 and 3 years - MAPS-HBSI and the recent FreeSurfer 6.0 Beta B (Build 20161008). Scatter plots of the 1 year versus 3 year BTB differences were found to be a particularly simple and effective way to display the segmentation noise of a method.

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