Abstract #4128

The disturbed subcortical local intrinsic activity synchronism in mild cognitive impairment and its association with spatial navigation ability: a resting-state fMRI study

Zhao Qing¹, Weiping Li¹, Wenbo Wu¹, Fangfang Wang¹, Renyuan Liu^1,2, Zuzana Nedelska^3,4, Jakub Hort³, Hui Zhao², Weibo Chen⁵, Queenie Chan⁶, Bin Zhu¹, Yun Xu², and Bing Zhang¹

¹Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, NanJing, People's Republic of China, ²Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, NanJing, People's Republic of China, ³Memory Disorders Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic, Czech Republic, ⁴International Clinical Research Center, St.Anne’s University Hospital Brno, Brno, Czech Republic, Czech Republic, ⁵Philips Healthcare, Shanghai, People's Republic of China, People's Republic of China, ⁶Philips Healthcare, HongKong, People's Republic of China, People's Republic of China

Loss of spatial navigation skills is a typical feature in mild cognitive impairment. Here we investigate intrinsic activity using resting-stat functional magnetic resonance imaging within the subcortical regions, which is previously reported to be important in spatial navigation. Right hippocampus, pallidum and thalamus showed significant decreased regional homogeneity of local intrinsic activity in the patients, and the correlational trend between regional homogeneity and allocentric navigation performance showed significantly difference between patients and normal aging controls. These results showed evidences for the intrinsic subcortical activity damage and a possible compensatory mechanism of spatial navigation in the early mild cognitive impairment.

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