We present a double-blind randomized cross-over clinical study that aims to investigate the efficacy of two weeks of repetitive transcranial magnetic stimulation (TMS) in modulating cognitive performances in patients with mild cognitive impairment (MCI) and to characterize in vivo brain connectivity changes in MCI patients after rTMS. We used a multi-modal approach based on behavioural tests, TMS-EEG, DWI and fMRI. The behavioural and neurophysiological results support the role of medial parietal region in memory process. Moreover, our findings suggest that TMS may be a potential effective strategy in treatment of MCI patients for whom, currently, there is no available therapy.
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