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Abstract #4129

A multi-modal study of the neural mechanisms behind the beneficial effects of repetitive TMS over the precuneus of MCI patients

Matteo Mancini1,2, Mara Cercignani2,3, Sonia Bonnì4, Silvia Picazio4, Viviana Ponzo4, Maria Concetta Pellicciari4, Elias Casula4, Laura Serra2, Carlo Caltagirone4, Giacomo Koch4,5, and Marco Bozzali2

1University of Rome "Roma Tre", Rome, Italy, 2Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy, 3Clinical Imaging Sciences Centre, University of Sussex, Brighton, United Kingdom, 4Non-Invasive Brain Stimulation Unit, Santa Lucia Foundation, Rome, Italy, 5Stroke Unit, Policlinico Tor Vergata, Rome, Italy

We present a double-blind randomized cross-over clinical study that aims to investigate the efficacy of two weeks of repetitive transcranial magnetic stimulation (TMS) in modulating cognitive performances in patients with mild cognitive impairment (MCI) and to characterize in vivo brain connectivity changes in MCI patients after rTMS. We used a multi-modal approach based on behavioural tests, TMS-EEG, DWI and fMRI. The behavioural and neurophysiological results support the role of medial parietal region in memory process. Moreover, our findings suggest that TMS may be a potential effective strategy in treatment of MCI patients for whom, currently, there is no available therapy.

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