Cerebral Blood Flow (CBF) as measured with ASL-MRI is an emerging Alzheimer’s Disease (AD) biomarker. However, vascular pathology may delay the arterial transit time (ATT) of the magnetic label and influence the measurement. Thus, ATT estimation can potentially reveal vascular pathology and benefit CBF quantification. To evaluate CBF and ATT as read-out markers in AD mouse models, time-encoded ASL was used to measure ATT and CBF in the APPswe/PS1ΔE9 AD model. No major CBF difference was found when ATT was taken into account. However, AD mice showed increased ATT in the thalamus and decreased CBF in the cortex and striatum.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords