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Abstract #4135

Using time-encoded pCASL to study vascular function in a mouse model of Alzheimer’s disease

Leon P. Munting1,2, Lydiane Hirschler3,4,5, Ernst Suidgeest1, Emmanuel L. Barbier3,4, Matthias J. P. van Osch1, and Louise van der Weerd1,2

1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Human Genetics, Leiden University Medical Center, Leiden, Netherlands, 3Grenoble Institut des Neurosciences, Université Grenoble Alpes, Grenoble, France, 4Inserm U836, Grenoble, France, 5Bruker Biospin, Ettlingen, Germany

Cerebral Blood Flow (CBF) as measured with ASL-MRI is an emerging Alzheimer’s Disease (AD) biomarker. However, vascular pathology may delay the arterial transit time (ATT) of the magnetic label and influence the measurement. Thus, ATT estimation can potentially reveal vascular pathology and benefit CBF quantification. To evaluate CBF and ATT as read-out markers in AD mouse models, time-encoded ASL was used to measure ATT and CBF in the APPswe/PS1ΔE9 AD model. No major CBF difference was found when ATT was taken into account. However, AD mice showed increased ATT in the thalamus and decreased CBF in the cortex and striatum.

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