Abstract #4136

Longitudinal progression of white matter deficits in Young Onset Alzheimer's Disease and Its Syndromic Variants using NODDI

Jiaying Zhang¹, Catherine F Slattery², Ross W Paterson², Alexander JM Foulkes², Laura Mancini^3,4, David L Thomas^3,4, Marc Modat¹, Nicolas Toussaint¹, David M Cash^1,2, John S Thornton⁵, Daniel C Alexander¹, Sebastien Ourselin¹, Nick C Fox², Jonathan M Schott², and Hui Zhang¹

¹Department of Computer Science and Centre for medical image computing, University College London, London, United Kingdom, ²Department of Neurodegenerative disease, Institute of Neurology, University College London, London, United Kingdom, ³Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK, University College London, London, United Kingdom, ⁴Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust, London, UK, University College London, ⁵Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust, London, UK, University College London, London, United Kingdom

Young Onset Alzheimer's disease (YOAD) is characterised by its syndromic diversity, which may be underpinned by different patterns of white matter (WM) network breakdown. This prompts considerable interest in studying WM. We have previously shown that NODDI, a multi-shell diffusion MRI technique, is more sensitive at detecting WM changes in YOAD than standard DTI and demonstrated unique profiles of WM deficits in its syndromic variants. Here we investigated longitudinal WM changes in YOAD patients using NODDI, and explored the patterns of longitudinal WM changes associated with syndromic variants using tract-based spatial statistics (TBSS).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.