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Abstract #4138

Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Normal Older Adults Investigated in vivo with 1H MRS and PiB PET

Gloria C Chiang1, Xiangling Mao2, Guoxin Kang3, Eileen Chang2, Sneha Pandya2, Shankar Vallabhajosula2, Richard Isaacson2, Lisa D Ravdin2, and Dikoma C. Shungu1

1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Radiology, Weill Cornell Medicine, 3Radidology, Weill Cornell Medicine

Oxidative stress has been implicated as an important pathological mechanism in the development of Alzheimer’s disease (AD). The purpose of this study was to assess whether J-edited 1H MRS levels of glutathione (GSH) – the primary antioxidant in living tissue – are associated with brain amyloidosis, as assessed with PET, and memory in a community-dwelling cohort of nondemented older adults. The results showed an inverse association relating GSH, a sensitive marker of oxidative stress, and amyloidosis, one of the pathological hallmarks of AD, and a weaker association with memory, thereby collectively further implicating oxidative stress in AD pathophysiology.

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