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Abstract #4139

Differentiation of deep gray matters in patients with Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) using T1 weighted images and quantitative susceptibility maps (QSM)

Eo-Jin Hwang1, Hyun Seok Choi 1, Jinhee Jang1, Seung Eun Jung1, So-Lyung Jung1, Kook-Jin Ahn1, Bum-soo Kim1, and Joong-Seok Kim1

1Seoul St.Mary Hospital, Seoul, Korea, Republic of

The purpose of this study was to differentiate Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) by evaluating deep gray matter regions of the three subject groups. The 3D T1 weighted images and quantitative susceptibility maps (QSM) were segmented into 15 deep gray matter structures to estimate volumes and mean susceptibility values, and differences among the three groups were evaluated using a one-way analysis of covariance (ANCOVA) with age and gender as covariates. A multivariate logistic regression and receiver operating characteristic curve analyses were performed to determine associated imaging features and diagnostic performance.

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