Abstract #4144

Co-activation Pattern Analysis in Parkinson’s Disease

Xiaowei Zhuang (co-first)¹, Ryan R Walsh (co-first)¹, Zhengshi Yang¹, Virendra Mishra¹, Karthik Sreenivasan¹, and Dietmar Cordes^1,2

¹Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ²University of Colorado Boulder, Boulder, CO, United States

In this study, we explored the dynamics of Parkinson’s disease (PD) brain network function utilizing the co-activation pattern (CAP) analysis emphasizing sensorimotor network (SM) function during resting-state. We modified the routine to calculate group dominant CAPs (d-CAPs) and proposed a novel way to obtain within-subject CAP switching-rate. Reduced dynamics of the SM network in PD was demonstrated by both decreased number of d-CAPs and decreased switching-rate, which corroborates electrophysiologic data.

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