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Abstract #4150

Abnormal Brain White Matter Connectivity in Diabetic Neuropathy: A Magnetic Resonance Diffusion Tensor Imaging Study.

Dinesh Selvarajah1, Joseph Harding1, Shillo Pallai1, Solomon tesfaye2, and Iain Wilkinson1

1University of Sheffield, Sheffield, United Kingdom, 2Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

This study for the first time has shown alterations in white matter MD in patients with DSPN. Increased MD in the primary somatosensory cortex in patients with diabetic neuropathy (DN) is suggestive of white matter microarchitecture degeneration, and supports the evidence of neuronal loss in the somatosensory cortex in patients with . Furthermore, these results also support the previous evidence of thalamic neuronal dysfunction in DN on MR spectroscopy. Changes in the degree of white matter structure might provide a pathophysiological underpinning of spinal cord atrophy and brain volume reduction in DN.

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