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Abstract #4152

Altered White Matter Microstructure in Middle-Aged Type 2 Diabetic Patients: A Diffusional Kurtosis Imaging Study Based on Two-compartment White Matter Model

Jie Gao1, Min Tang1, Xin Zhang1, Xiaoling Zhang1, Kaining Shi2, and Xiaohong Wu1

1Shaanxi Provincial People's Hospital, Xi'an, People's Republic of China, 2Clinical science, Philips Healthcare China

This study aims to use a two-compartment diffusion model of white matter based on diffusional kurtosis imaging (DKI) to explore early white matter alternations in middle-aged type 2 diabetes mellitus (T2DM) . 33 T2DM patients and 13 healthy control were enrolled. All diffusion parameters (FA=fractional anisotropy, MD=mean diffusivity, AD=axial diffusivity, RD=radial diffusivity, MK=mean kurtosis, AK=axial kurtosis, RK=radial kurtosis, Da=intra-axonal diffusivity, De∥=axial extra-axonal space diffusivity, De⊥= radial extra-axonal space diffusivity) were compared. De⊥ was demonstrated to be the most sensitive in detecting the diffusion changes. These increased De⊥ (extra-axonal diffusivity) and unchanged Da (intra-axonal diffusivity) reflected the increased water and/or demyelination.

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