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Abstract #4155

Reorganization of Brain Connectivity in the Speech and Language Network in the Non-fluent variant of PPA

Maria Luisa Mandelli1, Christa Watson1, Eduard Vilaplana2, Jesse A Brown1, Zachary A Miller1, Isabel H Honey1, Ariane Welch1, Miguel A Santos-Santos3, Howard J Rosen1, Bruce L Miller1, William W Seeley1, and Maria Luisa Gorno-Tempini1

1Memory and Aging Center, Neurology, University of California, San Francisco, San Francisco, CA, United States, 2Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau – Universitat Autonoma de Barcelona, Spain, 3Fundació ACE, Alzheimer Research Center, Institut Català de Neurociències Aplicades, Barcelona, Spain Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute, Barcelona, Spain

Graph theory analysis is a method recently introduced to study the brain as a network. In this study we investigate the topological distribution of the speech and language functional network in nfvPPA patients characterized by isolated and progressive language impairments. We identified the hubs of the speech and language network in healthy controls and nfvPPA. In patients, the network presented an abnormal topological distribution where right-sided brain regions were recruited. These findings suggest that in nfvPPA this network reorganizes in the presence of localized gray matter volume loss.

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