Abstract #4156

Sporadic Jakob-Creutzfeld Disease quantitative diffusion profiles and resting state functional correlates

Matteo Paoletti¹, Eduardo Caverzasi², Maria Luisa Mandelli³, Jesse A. Brown³, William W. Seeley³, Roland G. Henry^2,4, Howard J. Rosen³, Bruce L. Miller³, Maria Luisa Gorno-Tempini³, Stefano Bastianello^5,6, and Michael D. Geschwind³

¹Institute of Radiology, University of Pavia, Pavia, Italy, ²Department of Neurology, University of California, San Francisco, San Francisco, CA, ³Memory and Aging Center, University of California, San Francisco, San Francisco, CA, ⁴Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, ⁵Department of Neuroradiology, IRCCS C. Mondino Neurological Institute, University of Pavia, Pavia, Italy, ⁶Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

Diffusion restriction on MRI is an important diagnostic finding in sporadic Jakob-Creutzfeld disease. We performed group-wise quantitative cortical and subcortical grey matter mean diffusivity analysis at 3.0 T and tested feasibility of single-subject diffusivity restriction maps, that, compared to group-wise analysis, can better describe variable patterns of involvement in sJCD. DMN-related regions demonstrated prominent diffusion restriction; thus DMN functional connectivity was evaluated. DMN showed a increased connectivity in sJCD, that based on cross-sectional analysis seems to decrease along with clinical worsening. Resting-state fMRI may be a promising candidate to evaluate involvement in sJCD especially during the preclinical phase.

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