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Abstract #4156

Sporadic Jakob-Creutzfeld Disease quantitative diffusion profiles and resting state functional correlates

Matteo Paoletti1, Eduardo Caverzasi2, Maria Luisa Mandelli3, Jesse A. Brown3, William W. Seeley3, Roland G. Henry2,4, Howard J. Rosen3, Bruce L. Miller3, Maria Luisa Gorno-Tempini3, Stefano Bastianello5,6, and Michael D. Geschwind3

1Institute of Radiology, University of Pavia, Pavia, Italy, 2Department of Neurology, University of California, San Francisco, San Francisco, CA, 3Memory and Aging Center, University of California, San Francisco, San Francisco, CA, 4Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 5Department of Neuroradiology, IRCCS C. Mondino Neurological Institute, University of Pavia, Pavia, Italy, 6Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

Diffusion restriction on MRI is an important diagnostic finding in sporadic Jakob-Creutzfeld disease. We performed group-wise quantitative cortical and subcortical grey matter mean diffusivity analysis at 3.0 T and tested feasibility of single-subject diffusivity restriction maps, that, compared to group-wise analysis, can better describe variable patterns of involvement in sJCD. DMN-related regions demonstrated prominent diffusion restriction; thus DMN functional connectivity was evaluated. DMN showed a increased connectivity in sJCD, that based on cross-sectional analysis seems to decrease along with clinical worsening. Resting-state fMRI may be a promising candidate to evaluate involvement in sJCD especially during the preclinical phase.

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