Meeting Banner
Abstract #4161

Altered Structural Connectivity Networks in Young Adults Perinatally-infected with HIV

Mohammed Z Goryawala1, Elizabeth J Willen2,3,4, Anai M Cuadra2, and Varan Govind1

1Radiology, University of Miami, Miami, FL, United States, 2Pediatrics, University of Miami, Miami, FL, 3Pediatrics, University of Missouri, Kansas City, MO, 4Developmental and Behavioral Sciences, Children's Mercy, Kansas City, MO

Milder forms of HIV-associated neurocognitive disorders (HAND) are frequently observed in approximately half of the HIV-infected individuals, even with treatment for HIV infection. Cognitive deficits observed in them can be associated with injury to the frontal and temporal lobes of their brains. The goal of this study was to assess the impact of HIV infection on vulnerable structural connections in these lobar regions in adults perinatally-infected with HIV. Our results indicate that altered connectivity in frontal lobe regions with differentiated modularity and significant alterations in hub patterns at the temporo-parietal junction occurred in the HIV group.

This abstract and the presentation materials are available to members only; a login is required.

Join Here