Abstract #4162

Susceptibility-related phase contrast associated with the alterations of myelo-architecture in adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia

Hansol Lee¹, Minkyeong Kim², HyungJoon Cho¹, Se Young Chun³, Gi Yeong Huh⁴, Eun-Joo Kim⁵, and Jae-Hyeok Lee⁶

¹Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, ²Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of, ³Department of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, ⁴Department of Forensic Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of, ⁵Department of Neurology, Pusan National University Hospital, Busan, Korea, Republic of, ⁶Department of Neurology, Pusan National University Yangsan Hospital

To investigate the origin of susceptibility-weighted imaging (SWI) contrast in frontal white matters of adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia (ALSP), we performed a combined post-mortem magnetic resonance imaging (MRI) and histological study of ALSP pathology. The myelin architectural changes, marked central myelin loss with preserved U-fibers beneath cortical gray matter, mainly contributed to the susceptibility contrast.

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