Abstract #4163

Assessment of chemotherapy-induced brain structural alterations in breast cancer patients using GQI and its correlation with cognitive performance

Tsung-Yuan Li^1,2, Vincent Chin-Hung Chen^3,4, Shu-Ling Huang⁵, Dah-Cherng Yeh⁶, Jyh-Wen Chai², Clayton Chi-Chang Chen², and Jun-Cheng Weng^1,7

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, ³School of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁴Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Department of Psychology, Chung Shan Medical University, Taichung, Taiwan, ⁶Breast Center, Taichung Tzu Chi Hospital, Taichung, Taiwan, ⁷Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Neuroimaging studies suggest that white matter and cognitive function changes were affected by breast cancer and its treatments. Our study interested in the early effect of the brain by chemotherapy. This study included 19 breast cancer survivors who had completed their chemotherapy and 20 healthy control group. Generalized q-sampling imaging (GQI) with voxel-based analysis was performed to show the brain structural differences between two groups. Multiple regression was also used to detect the correlation between Mini-Mental State Examination (MMSE) and the indices of GQI. Our results provided further evidence that breast cancer and adjuvant chemotherapy are associated with adverse effects on white matter.

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