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Abstract #4164

The association of MRI-detected brain volume change with prenatal exposure to Perfluoroalkyl Substances in teenage

Chao-Yu Shen1,2,3, Shu-Li Wang4, Jeng-Dau Tasi5, Ju-Chien Wu2, and Jun-Cheng Weng2,3

1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 2Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 3Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, 4National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan, 5School of Medicine and Department of Pediatrics, Chung Shan Medical University and Hospital, Taichung, Taiwan

The current study was to explore the relationship between prenatal exposure to PFASs, determined in maternal blood collected during the third trimester of pregnancy and the children’s brain volume difference at the age of 13-15 years old. The results showed a significant negative correlation between the maternal blood PFASs concentrations and the children's brain MRI in multiple different brain areas, including both gray matter and white matter.

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