Progressive Supranuclear Palsy (PSP) is an atypical Parkinsonism, which shared similar symptoms with Parkinson’s disease (PD) and PSP progressed typically much faster than PD and the prognosis is often poor. The linear regression analysis demonstrated the capability of diffusion MRI indices as measured from multiple brain regions in the prediction of two-year clinical severity. Strong predictive power can be observed in mHY, motor subscale of UPDRS and PIGD. The two-year clinical decay in patients with PSP can be accurately predicted by using diffusion tensor derived parameters as measured from distinct brain regions.
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