Abstract #4170

Three-dimensional pseudo-continuous arterial spin labeling(3D-pcASL) in differentiating tumor progression from treated effects in glioma

Yuelei Lyu^1,2, Bo Hou ¹, Shuai Liu ³, Hui You¹, Yu Wang³, Wenbin Ma ³, and Feng Feng¹

¹Department of Radiology, Peking Union Medical College Hospital, Beijing, People's Republic of China, ²Department of Radiology, Beijing Chao-Yang Hospital, Beijing, People's Republic of China, ³Department of Neurosurgery, Peking Union Medical College Hospital, Beijing, People's Republic of China

This study investigates the role of 3D-pcASL in discriminating between glioma progression(TP)and treatment related changes(TRC). We found that the maximum CBF (absolute value and its normalized values) in the lesion from 3D-pcASL were significantly higher in the TP group than in the TRC group. The ROC curve analysis showed the maximum CBF has an excellent performance in differentiating TP from TRC in patients with newly diagnosed glioma who have undertaken radiotherapy or chemoradiotherapy.

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