Abstract #4171

Proposed thresholds for parametric response mapping using intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) for the assessment of brain tumor treatment response

Ashley M Stokes¹, Jack T Skinner², Laura C Bell¹, Adrienne N Dula³, Thomas E Yankeelov³, and C. Chad Quarles¹

¹Translational Bioimaging Group, Barrow Neurological Institute, Phoenix, AZ, United States, ²Imaging Programs, National Comprehensive Cancer Network (NCCN), Philadelphia, PA, United States, ³University of Texas - Austin

The purpose of this study is to establish thresholds for parametric response mapping (PRM) using apparent diffusion coefficients (ADC) and intra-voxel incoherent motion (IVIM) parameters in healthy controls and to apply these thresholds in a cohort of brain tumor patients to study regional treatment-induced changes in diffusion and perfusion. We obtained thresholds (95% confidence intervals) of 0.38 and 0.32 x10^-3 mm²/s for ADC and IVIM-D, respectively. For the perfusion-related distributions, the thresholds were 10 ml/100g (IVIM-f_p) and 54 ml/100g/min (IVIM-f_pD*). This multi-parametric sensitivity to local tumor changes could be useful to simultaneously evaluate treatment-induced changes in perfusion and cellularity.

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