We evaluate the reproducibility of ktrans values derived from dynamic contrast MRI images in patients with newly diagnosed glioblastoma. Particular focus is put on the reproducibility across choices of T1 values and arterial input functions (AIFs) to the Tofts-Kermode model. Reproducibility is assessed across multiple pre-therapy baseline visits in a 45 patient cohort. Our model based on static population AIFs and static global T1 values had excellent reproducibility compared to other models including unique individual AIFs and T1 maps. There is relatively little concordance between all tested models, but individual AIFs led to higher mean ktrans values.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords