Abstract #4180

Perfusion imaging of brain gliomas using arterial spin labeling: Correlation with histopathological vascular density in MRI-guided biopsies

Haopeng Pang¹, Ningning Di¹, Chengjun Yao², Yan Ren¹, Jingsong Wu ³, Yong Zhang⁴, Jianxun Qu ⁴, and Zhenwei Yao ¹

¹Radiology, Huashan Hospital, Shanghai, People's Republic of China, ²Glioma Surgery Division, Huashan Hospital, Shanghai, People's Republic of China, ³Neurosurgery, Huashan Hospital, Shanghai, People's Republic of China, ⁴MR Research China, GE Healthcare, Shanghai, People's Republic of China

This study was designed to determine if CBF derived from ASL perfusion imaging could be used to quantitatively evaluate the MVD of brain gliomas on a “point-to-point” basis. The study enrolled 47 patients with treatment-naive brain gliomas who underwent preoperative ASL before stereotactic surgery. We histologically quantified MVD from CD34-stained sections of stereotactic biopsies and co-registered biopsy locations with localized CBF measurements. CBF showed a statistically significant positive correlation with MVD. ASL can be a quantitative and noninvasive perfusion MR method for evaluating the MVD of brain gliomas, and may reflect the microvascularity of gliomas.

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