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Abstract #4181

Non-invasive, contrast-exempt (NICE) assessment of glioblastoma (GBM) using multi-slice ASL and iVASO imaging

Jalal B. Andre1, S Kristie McKown2, and Swati Rane2

1Radiology, University of Washington, Seattle, WA, United States, 2University of Washington

Assessment of cerebral and tumor perfusion has frequently been advocated for initial prognostication, and evaluation for possible progression, of primary brain tumors, historically accomplished via intravenous injection of a gadolinium-based contrast agent (GBCA). The potential for intracranial and corporeal deposition of GBCA invites the development and optimization of non-invasive, contrast-exempt (NICE) methods to assess cerebral perfusion. We sought to develop and implement NICE spin-label-based methods incorporating cerebral blood flow (CBF) and volume (CBV) assessment, applied in treated GBM patients.

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