Abstract #4211

Decreased Brain Nicotinamide Adenine Dinucleotide (NAD) Levels in Adolescent Bipolar Disorder

Young-Hoon Sung^1,2, Xian-Feng Shi^1,2, Perry F. Renshaw^1,2,3, and Douglas G. Kondo^1,2,3

¹Brain Institute, Salt Lake City, UT, United States, ²University of Utah Department of Psychiatry, Salt Lake City, UT, United States, ³Veterans Administration Rocky Mountain MIRECC for Suicide Prevention, Salt Lake City, UT, United States

Converging evidence implicates mitochondrial dysfunction in bipolar disorder (BPD). Treatments of adolescent BPD have limited efficacy, and are associated with significant toxicity. Phosphorus magnetic spectroscopy imaging (³¹P MRSI) may shed light on the pathophysiology and neural markers of adolescent BPD. In the present study, nicotinamide adenine dinucleotide (NAD) levels were measured using ³¹P MRSI in 15 adolescents with BPD and 23 healthy controls (HC). BPD adolescents had significantly decreased NAD levels compared to HC. Clinical trials of NAD precursors are required to determine whether restoration of NAD levels is feasible, and can serve as a treatment for adolescent BPD.

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