We analyzed the white matter (WM) asymmetry in a relatively large sample of drug-naïve schizophrenia patients under different genetic load. Based on this method, our findings demonstrated similar overall WM brain torque in sporadic and familial schizophrenia patients and healthy controls. Furthermore, our observation that familial illness was associated with more abnormal brain asymmetry compared to sporadic patients and that these specific changes were mainly located in a functional network associated with auditory hallucinations suggesting genetic factors may play critical roles in impacting risk for the most common form of hallucinations in schizophrenia.
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