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Abstract #4213

Connectome-wide exploration of altered resting-state connectivity in combat veterans with and without PTSD and real-time fMRI neurofeedback training effect on abnormal connectivity

Masaya Misaki1, Raquel Phillips1, Vadim Zotev1, Chung Ki Wong1, Frank Krueger2, Matthew Feldner3, and Jerzy Bodurka1,4

1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Department of Psychology, George Mason University, Fairfax, VA, United States, 3Deptartment of Psychological Science, University of Arkansas, Fayetteville, AR, United States, 4College of Engineering, Stephenson School of Biomedical Engineering, University of Oklahoma, Tulsa, OK, United States

In combat veterans with and without PTSD diagnosis, we performed connectome-wide exploration of the whole-brain voxel-by-voxel fMRI connectivity using multivariate distance-based matrix regression (MDMR) analysis to determine connectivity abnormalities without a priori hypothesis. PTSD veterans showed increased connectivity across sensory motor areas and the superior temporal to default mode network (DMN) areas compared to non-trauma-exposed control. Veterans without PTSD also showed altered connectivity in the bilateral insula compared to control. This abnormal connectivity pattern was normalized after real-time fMRI neurofeedback training focused on learning to control left amygdala activity with positive autobiographical memory recall.

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