The current study, for the first time, integrated voxel-wise univariate analysis and multivariate pattern classification approach to evaluate the alterations of localized neural connectivity in a relatively large sample of drug-naive patients with obsessive-compulsive disorder (OCD). Our findings (i) suggested the disequilibrium between the fronto-parietal circuit and the cerebellum might be associated with the pathophysiology of OCD, (ii) indicated the translational role of the localized neural connectivity as a potential discriminative pattern to identify OCD at the individual level and (iii) highlighted the hyperactivation of the prefrontal cortex in the pathophysiologic process of OCD.
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