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Abstract #4216

The ability of magnetic resonance spectroscopy to measure metabolite changes in response to ketamine in major depression at 7T

Jennifer Evans1, Niall Lally1, Li An1, Allison Nugent1, and Carlos Zarate1

1NIMH, NIH, Bethesda, MD, United States

This study investigates the feasibility of measuring glutamate and glutamine metabolites by 7T 1H-MRS after a ketamine infusion in a double blind placebo cross-over study in major depression. MRS data was acquired from the pre-genual anterior cingulate in 15 depressed and 13 healthy controls. Glutamate levels, but not glutamine, were found to be significantly different between groups.

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