Abstract #4218

Accumulation of Prefrontal Lactate Levels in Chronic Schizophrenia

Lijing Xin¹, Philipp S Baumann^2,3, Raoul Jenni^2,3, Luis Alameda^2,3, Carina Ferrari^2,3, Philippe Conus³, Rolf Gruetter^4,5, and Kim Q Do²

¹Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ³Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁴Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁵Departments of Radiology, University of Lausanne and Geneva, Lausanne and Geneva, Switzerland

Mitochondrial dysfunction including altered brain energy metabolism has been implicated in the pathophysiology of schizophrenia. The aim of this study was to investigate prefrontal lactate(Lac) levels in patients with chronic schizophrenia. An increase of [Lac_mPFC] was observed in patients with chronic schizophrenia relative to healthy controls. This may be associated with glucose metabolism impairment and mitochondrial dysfunction resulting from oxidative stress. Indeed, oxidative damages can impair mitochondrial oxidative phosphorylation and enzyme activities of pyruvate dehydrogenase, leading to Lac production. Therefore, this study provides in vivo evidence supporting that oxidative stress and mitochondrial dysfunction may be involved in schizophrenia.

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