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Abstract #4219

Brain Cortical Thickness in Adolescents from Multiplex Alcohol Dependence Families

Bharath Holla1, Rajanikanth Panda2, Ganesan Venkatasubramanian3, Rose Dawn Bharath2, and Vivek Benegal1

1Centre for Addiction Medicine and Department of Psychiatry, National Institute of Mental Health & Neuro Sciences (NIMHANS), Bangalore, India, 2Cognitive Neuroscience Centre and Department of Neuroimaging and Interventional Radiology (NIIR), National Institute of Mental Health & Neuro Sciences (NIMHANS), Bangalore, India, 3Translational Psychiatry Laboratory and Department of Psychiatry, National Institute of Mental Health & Neuro Sciences (NIMHANS), Bangalore, India

Adolescents with high familial-loading of alcoholism exhibit altered premorbid subcortical and cerebellar brain-volumes compared to their peers. They also differ in brain-activity during executive-functioning, reward, and emotion-processing tasks. However, the changes in the maturation of the cortical thickness during the adolescence in these high-risk (HR) individuals and their relationship with the externalizing-behaviors have never been examined. Our findings reveal wide-spread delays in cortical maturation in HR subjects, which may ultimately contribute to their addiction vulnerability. More importantly, these effects reduce with age by late-adolescence in the absence of substance-misuse. Additionally, cortical thinning was associated with better behavioral control across groups

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