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Abstract #4220

Proton magnetic resonance spectroscopy study of amygdala, anterior cingulate cortex and thalamus in pediatric post-traumatic stress disorder patients

Weina Wang1, Xiaorui Su2, Qiyong Gong2, and Qiang Yue2

1Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China, 2West China Hospital of Sichuan University, People's Republic of China

PTSD is associated with a variety of structural and functional brain abnormalities, but the molecular pathophysiological mechanisms are unknown. 25 pediatric PTSD and 24 matched healthy control subjects underwent single voxel 1H-MRS. Right amygdala NAA was significantly increased in pediatric PTSD subjects than in controls, and the other metabolites did not differ significantly between the groups. We hypothesis that long-term excessive activation in amygdala after traumatic events may lead to increase density and activity of the neurons in pediatric PTSD patients with increased NAA concentration, which may be an adaptive response to traumatic stimulation in the human brain. Our findings add the neurochemical abnormality evidence in pediatric PTSD.

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