Meeting Banner
Abstract #4221

Disruptions in T1-weighted MRI signal trajectories over age in Bipolar Disorder Type-1

Christopher Dennis Rowley1, Manpreet Sehmbi1, Luciano Minuzzi2, Benicio Frey2, and Nicholas Bock3

1Neuroscience, McMaster University, Hamilton, ON, Canada, 2Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada, 3Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada

T1-weighted signal is known to be correlated with age and myelin content. T1-weighted images with optimized intracortical contrast were taken in subjects aged 17-45. The half cortical depth signal was mapped in 67 healthy controls and 43 individuals diagnosed with bipolar disorder type-1. We investigated the trajectory of the signal with age in each group and it was found that healthy signal trajectory follows a quadratic form with age, while no correlation with age was found in bipolar disorder. We have shown that it is possible to map signal trajectory changes in clinical populations across the cortex.

This abstract and the presentation materials are available to members only; a login is required.

Join Here