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Abstract #4222

Resting-state functional connectivity abnormalities associated with posttraumatic stress disorder and traumatic stress: a graph-based analysis

Lei Li1, Xinyu Hu1, Xiaoqi Huang1, and Qiyong Gong1

1Department of Radiology, Huaxi MR Research Center, Chengdu, People's Republic of China

Previous studies have clarified that differentiating the disease- and traumatic stress-related brain changes may elucidate the core neural mechanism of PTSD. This study is to investigate brain functional alterations in PTSD and the traumatic exposed controls (TEC) relative to the non-traumatized healthy controls (HC) separately, using a data-driven graph theoretical approach--whole-brain functional connectivity strength (FCS) mapping. The current study provided the preliminary evidence of common and separate abnormalities of neural correlates at whole-brain level associated with PTSD and traumatic stress. The disequilibrium between the DMN and the SN might be associated with the pathophysiology of PTSD.

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