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Abstract #4224

Detailed T1-weighted laminar profiles from the human cortex measured in vivo at 3T and validated at 7T

Bart Ferguson1, Natalia Petridou2, Alessio Fracasso2,3, Martijn P Van den Heuvel1, Rachel M Brouwer1, Hilleke E Hulshoff Pol1, Rene S Kahn1, and Rene C W Mandl1,4

1Psychiatry, UMC Utrecht, Utrecht, Netherlands, 2Radiology, UMC Utrecht, Utrecht, Netherlands, 3Experimental Psychology, Utrecht University, Utrecht, Netherlands, 4CNSR, Psykiatrisk Center Glostrup, Glostrup, Denmark

Patients with schizophrenia show cortical gray matter thinning but it is unknown whether all six cortical layers are implicated or that specific layers are affected. Knowing which layers are involved gives more insight in the underlying pathophysiological processes of schizophrenia. Here we present a method to compute detailed laminar profiles per brain area from conventional 3T T1-weighted scans, which can be used to obtain information on relative layer organization. We validate this method by comparing average profiles computed from conventional 3T scans to profiles computed from high resolution scans, acquired at ultra-high field MRI (7T).

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