Abstract #4225

The acute pharmacological MRI response to a citalopram challenge is modulated by earlier selective serotonin reuptake inhibitor exposure in an age dependent manner

Michelle Solleveld^1,2, Anouk Schrantee¹, Henk-Jan Mutsaerts^1,3, Paul Lucassen², and Liesbeth Reneman¹

¹Department of Radiology, Academic Medical Center Amsterdam, Amsterdam, Netherlands, ²Swammerdam Institute for Life Sciences, Center for Neurosciences, University of Amsterdam, Amsterdam, Netherlands, ³Sunnybrook Research Institute, University of Toronto, Toronto, Canada

Preclinical studies have shown that selective serotonin reuptake inhibitor (SSRI) treatment, when applied to the developing brain, is associated with long-term changes in the adult serotonergic system. Using pharmacological MRI (phMRI), we here investigated whether SSRIs can also induce such age-dependent changes in the human serotonergic system. We found that the phMRI response to citalopram was decreased in the amygdala only in adult female subjects who had been first exposed to SSRIs early in life, whereas a blunted response was found in subjects first exposed at a later age.

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