Meeting Banner
Abstract #4230

Measuring Alanine in Schizophrenia using 2D Correlation Spectroscopy

Adrienne Lee1, Luke Wang1,2, Benjamin Rowland1, Vicky Liao1, Elisabetta Del Re3, Robert McCarley3, and Alexander Lin1

1Center for Clinical Spectroscopy, Brigham and Women’s Hospital, Boston, MA, United States, 2Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA, 3Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Boston, MA

Degree of schizophrenia (SZ) was determined by phase-locking factor (PLF) acquired through an electroencephalogram (EEG). Correlation spectroscopy (COSY) spectra of the chronic SZ patients and age-matched healthy controls were then compared. A significant difference (p < 0.05) between SZ and controls was found in the concentrations of alanine supported by a strong correlation between PLF and alanine levels. These results suggest further studies to examine alanine as a potential biomarker for schizophrenia.

This abstract and the presentation materials are available to members only; a login is required.

Join Here