The general goal of this study is to determine the volume changes of cortical and subcortical brain regions in smoking and currently non-smoking alcohol-dependent individuals during short-term and long-term abstinence from alcohol, compared with non-/light-drinking controls. Preliminary results from paired t-tests within each group show that the anterior cingulate cortex, dorsolateral prefrontal cortex, orbitofrontal cortex, insula, and hippocampus have different recovery patterns, which suggest potentially different neuropathological changes and/or injuries. More statistical analyses will test for cross-sectional and longitudinal differences between the groups for a better interpretation of the regional volume changes and their cognitive and behavioral correlates.
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