Meeting Banner
Abstract #4231

Regional Brain Volume Changes in Alcohol-dependent Individuals during Short-term and Long-term Abstinence

Xiaowei Zou1,2, Timothy C. Durazzo3,4, and Dieter J. Meyerhoff1,2

1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA, United States, 3Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States, 4Mental Illness Research and Education Clinical Centers and Sierra-Pacific War Related Illness and Injury Study Center, VA Palo Alto Health Care System, CA, United States

The general goal of this study is to determine the volume changes of cortical and subcortical brain regions in smoking and currently non-smoking alcohol-dependent individuals during short-term and long-term abstinence from alcohol, compared with non-/light-drinking controls. Preliminary results from paired t-tests within each group show that the anterior cingulate cortex, dorsolateral prefrontal cortex, orbitofrontal cortex, insula, and hippocampus have different recovery patterns, which suggest potentially different neuropathological changes and/or injuries. More statistical analyses will test for cross-sectional and longitudinal differences between the groups for a better interpretation of the regional volume changes and their cognitive and behavioral correlates.

This abstract and the presentation materials are available to members only; a login is required.

Join Here